Running from 1665 to 1666 AD, this was the last major outbreak of the bubonic plague in England, and occurred during the Second Pandemic (a centuries-long period of intermittent bubonic plague epidemics originating in Central Asia in 1331 AD). This was also known as the Black Death, which was carried by rats on ships.
It is estimated that around 100,000 people died within the span of 18 months. Although not as many were killed compared to other, earlier, outbreaks, it was named the ‘great’ plague due to how widespread it was. However, it is possible that the plague would have continued for longer, if not for the Great Fire of London…